Cellulose Acetate/Chitosan Multimicrospheres Preparation and Ranitidine Hydrochloride Release In Vitro

Hui Yun Zhou

‌, Xi Guang Chen, Dr.

‌, Cheng Sheng Liu

‌, Xiang Hong Meng

‌, Chen Guang Liu

‌, Jun He

‌ and Le Jun Yu

‌

College of Marine Life Science, Ocean University of China, Qingdao, P. R. China

College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, P. R. China

A noval cellulose acetate/chitosan multimicrospheres (CACM) was prepared by the method of w/o/w emulsion. The concentration of cellulose acetate (CA) and the ratio of CA/chitosan (CS) had influence on the CACM size, and appearance. Ranitidine hydrochloride loading, and releasing efficiency in vitro were investigated. The optimal condition for preparation of the microspheres was CA concentration at 2% and the ratio of CA/CS at 3/1. The microspheres size was 200–350 μm. The appearance of microspheres was spherical, porous, and nonaggregated. The highest loading efficiency was 21%. The ranitidine release from the CACM was 40% during 48 hr in buffers.

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Forward Links to Citing Articles

Xiaoyu Zhang, Fenghua Chen, Jiazuan Ni. (2009) A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system. Drug Delivery 16:5, 280-288
Online publication date: 1-Jul-2009.
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