Calpain inhibitory flavonoids isolated from Orostachys japonicus

Choong Je Ma

‌^1,2, Won Joo Jung

‌¹, Ki Yong Lee

‌¹, Young Choong Kim

‌¹, Sang Hyun Sung

‌¹

¹College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, 151-742, Republic of Korea

²School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 200-701, Republic of Korea

Address for Correspondence:

S. H. Sung, College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San56-1, Shilim-Dong, Gwanak-Gu, Seoul 151-742, Republic of Korea. Tel: 82 2 880 7859. Fax: 82 2 877 7859. E-mail: shsung@snu.ac.kr

The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-α-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (6) and quercitrin (7) were obtained. Their structures were determined by spectroscopic techniques. Among them, compound 3 and 5 had significant calpain inhibitory activities.

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