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Summary
July 2007, Vol. 7, No. 7, Pages 965-973
, DOI 10.1517/14712598.7.7.965
The therapeutic potential of mesenchymal stem cellsCell- & Tissue-based Therapy Sonia C Picinich †1, Pravin J Mishra2, Prasun J Mishra1, John Glod1,3 & Debabrata Banerjee1,21University of Medicine and Dentistry of New Jersey, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA 2University of Medicine and Dentistry of New Jersey, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Department of Medicine, 195 Little Albany Street, New Brunswick, NJ 08903, USA 3University of Medicine and Dentistry of New Jersey, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Department of Pediatric Oncology, 195 Little Albany Street, New Brunswick, NJ 08903, USA †  Author for correspondence University of Medicine and Dentistry of New Jersey, Cancer Institute of New Jersey Robert Wood Johnson Medical School Department of Pharmacology 195 Little Albany Street New Brunswick NJ 08903 USA +1 732 235 8185 +1 732 235 8181 picinisc@umdnj.edu Mesenchymal stem cells (MSCs) are multipotent cells with a number of potential therapeutic applications. At present, they are being used in a clinical trial for the treatment of myocardial infarction and are being studied as a therapy for other vascular disorders. Treatments of neurologic disorders and anticancer therapy with MSCs have progressed in light of the migratory properties of MSCs to brain injury and tumors. The osteogenic potential of MSCs is being exploited in work investigating their use in bone regeneration therapy, and the immunomodulatory function of MSCs is being evaluated as a possible therapy for graft-versus-host disease. Here, the authors review recent work contributing to the knowledge of MSC biology and the advances in gene therapy and tissue regeneration using MSCs. Forward Links to Citing ArticlesY. Tabata. (2009) Biomaterial technology for tissue engineering applications. Journal of The Royal Society Interface 6:Suppl_3, S311-S324 Online publication date: 6-Jul-2009. CrossRef A. LIRAS, S. OLMEDILLAS. (2009) Gene therapy for haemophilia…yes, but…with non-viral vectors?. Haemophilia Online publication date: 1-Apr-2009. CrossRef Toru Hiraga, Tadashi Ninomiya, Akihiro Hosoya, Masafumi Takahashi, Hiroaki Nakamura. (2009) Formation of bone-like mineralized matrix by periodontal ligament cells in vivo: a morphological study in rats. Journal of Bone and Mineral Metabolism 27:2, 149-157 Online publication date: 1-Apr-2009. CrossRef Masatoshi Suzuki, Jacalyn McHugh, Craig Tork, Brandon Shelley, Antonio Hayes, Ilaria Bellantuono, Patrick Aebischer, Clive N Svendsen. (2009) Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS. Molecular Therapy 16:12, 2002-2010 Online publication date: 1-Jan-2009. CrossRef Tong Wang, Wanchun Tang, Shijie Sun, Tingyan Xu, Hao Wang, Jun Guan, Zitong Huang, Max Harry Weil. (2008) Intravenous infusion of bone marrow mesenchymal stem cells improves brain function after resuscitation from cardiac arrest. Critical Care Medicine 36:Suppl, S486-S491 Online publication date: 1-Dec-2008. CrossRef H. Ohtaki, J. H. Ylostalo, J. E. Foraker, A. P. Robinson, R. L. Reger, S. Shioda, D. J. Prockop. (2008) Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proceedings of the National Academy of Sciences 105:38, 14638-14643 Online publication date: 5-Oct-2008. CrossRef Antonio Orlacchio, Giorgio Bernardi, Aldo Orlacchio, Sabata Martino. (2008) Patented therapeutic RNAi strategies for neurodegenerative diseases of the CNS. Expert Opinion on Therapeutic Patents 18:10, 1161-1174 Online publication date: 1-Oct-2008. Summary
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| PDF Plus (345 KB) Elise Esneault, Emilie Pacary, Dauphou Eddi, Thomas Freret, Emmanuelle Tixier, Jérôme Toutain, Omar Touzani, Pascale Schumann-Bard, Edwige Petit, Simon Roussel, Myriam Bernaudin. (2008) Combined therapeutic strategy using erythropoietin and mesenchymal stem cells potentiates neurogenesis after transient focal cerebral ischemia in rats. Journal of Cerebral Blood Flow & Metabolism 28:9, 1552-1563 Online publication date: 1-Oct-2008. CrossRef M JAWAD JAVED, LAURA E. MEAD, DANIEL PRATER, WAYLAN K. BESSLER, DAVID FOSTER, JAMIE CASE, W SCOTT GOEBEL, MERVIN C. YODER, LAURA S. HANELINE, DAVID A. INGRAM. (2008) Endothelial Colony Forming Cells and Mesenchymal Stem Cells are Enriched at Different Gestational Ages in Human Umbilical Cord Blood. Pediatric Research 64:1, 68-73 Online publication date: 1-Aug-2008. CrossRef J. Ringe, I. Leinhase, S. Stich, A. Loch, K. Neumann, A. Haisch, T. Häup, R. Manz, C. Kaps, M. Sittinger. (2008) Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 2:2-3, 136-146 Online publication date: 1-Apr-2008. CrossRef Monica R Walker, Thaddeus S Stappenbeck. (2008) Deciphering the ???black box??? of the intestinal stem cell niche: taking direction from other systems. Current Opinion in Gastroenterology 24:2, 115-120 Online publication date: 1-Apr-2008. CrossRef Prasun J Mishra, Glenn Merlino. (2008) A traitor in our midst: mesenchymal stem cells contribute to tumor progression and metastasis. Future Oncology 4:6, 745 CrossRef
| Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies Smita S Iyer, Mauricio RojasSummary
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