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Summary
February 2008, Vol. 8, No. 2, Pages 213-220
, DOI 10.1517/14712598.8.2.213
Oncolytic measles virus strains in the treatment of gliomasCory Allen1Mayo Clinic, Molecular Medicine Department, 200 First Street SW, Rochester, MN 55905, USA +1 507 284 2511; +1 507 284 1803; galanis.evanthia@mayo.edu 2Mayo Clinic, Division of Medical Oncology, 200 First Street SW, Rochester, MN 55905, USA †  Author for correspondenceBackground: Recurrent gliomas have a dismal outcome despite use of multimodality treatment including surgery, radiation therapy and chemotherapy. Objective: In this article the authors discuss potential applications of oncolytic measles virus strains as novel antitumor agents in the treatment of gliomas. Methods: Important aspects of measles virus development as an anticancer therapeutic agent including engineering, retargeting and combination studies with other therapeutic modalities are discussed. The translational process that led to the first clinical trial of an engineered measles virus derivative in patients with recurrent glioblastoma multiforme is also described. Results/conclusions: Oncolytic measles virus strains hold promise as novel antitumor agents in the treatment of gliomas. Forward Links to Citing ArticlesPavlos Msaouel, Ianko D. Iankov, Cory Allen, John C. Morris, Veronika von Messling, Roberto Cattaneo, Michael Koutsilieris, Stephen J. Russell, Evanthia Galanis. (2009) Engineered measles virus as a novel oncolytic therapy against prostate cancer. The Prostate 69:1, 82-91 Online publication date: 1-Feb-2009. CrossRef Rae Myers, Mary Harvey, Timothy J. Kaufmann, Suzanne M. Greiner, James W. Krempski, Corey Raffel, Steven E. Shelton, Diane Soeffker, Paula Zollman, Mark J. Federspiel, Michael Blanco, Evanthia Galanis. (2008) Toxicology Study of Repeat Intracerebral Administration of a Measles Virus Derivative Producing Carcinoembryonic Antigen in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas. Human Gene Therapy 19:7, 690-698 Online publication date: 1-Aug-2008. CrossRef Users who read this article also read:
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