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Summary
June 2000, Vol. 4, No. 3, Pages 265-296
, DOI 10.1517/14728222.4.3.265
New potential targets for antifungal developmentElizabeth A WillsDepartment of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC 27710, USA. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Medicine and Department of Microbiology, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC 27710, USA. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Laboratory of Fungal Metabolism and Diseases, Hollings Cancer Center, Rooms 311, 351, PO Box 250780 - 86 Jonathan Lucas Street, Charleston, SC 29425, USA. delpoeta@musc.edu and Infectious Diseases and Public Health, University of Ancona, Ancona, 60121, Italy. With the increasing number of immunocompromised hosts and advances in medical technology there has been a concomitant rise in the number of cases of invasive fungal infections. Novel approaches for the discovery of new antifungal targets and their inhibitors will be needed. In this review we discuss how such approaches are being developed through the identification of novel biochemical and molecular targets to meet the challenges imposed by the scientific research in medical mycology. Forward Links to Citing ArticlesPenelope R. Chua, David M. Roof, Yan Lee, Roman Sakowicz, David Clarke, Dan Pierce, Thoryn Stephens, Matthew Hamilton, Brad Morgan, David Morgans. (2007) Effective killing of the human pathogen Candida albicans by a specific inhibitor of non-essential mitotic kinesin Kip1p. Molecular Microbiology 65:2, 347 CrossRef |
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