Summary
November 2004, Vol. 1, No. 1, Pages 57-65 , DOI 10.1517/17425247.1.1.57

Carbon nanotubes for the delivery of therapeutic molecules

Alberto Bianco
Institut de Biologie Moléculaire et Cellulaire, UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, 15, Rue René Descartes, 67084 Strasbourg Cedex, France. A.Bianco@ibmc.u-strasbg.fr



Functionalised carbon nanotubes (f-CNTs) are emerging as new tools in the field of nanobiotechnology and nanomedicine. This is because they can be easily manipulated and modified by encapsulation with biopolymers or by covalent linking of solubilising groups to the external walls and tips. The possibility of incorporating f-CNTs into biological systems has opened the way to the exploration of their potential applications in biology and medicinal chemistry. Within the different fields of applications (i.e., biosensors, composite materials, molecular electronics), one use of CNTs is as new carrier systems for the delivery of therapeutic molecules. Research discussed in this review is focused on recent advances in the development of CNT technology for the delivery of drugs, antigens and genes.

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Forward Links to Citing Articles

Yitzhak Rosen, Noel M Elman. (2009) Carbon nanotubes in drug delivery: focus on infectious diseases. Expert Opinion on Drug Delivery 6:5, 517-530
Online publication date: 1-May-2009.
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Gianni Ciofani, Yosuke Obata, Izumi Sato, Yosuke Okamura, Vittoria Raffa, Arianna Menciassi, Paolo Dario, Naoya Takeda, Shinji Takeoka. (2009) Realization, characterization and functionalization of lipidic wrapped carbon nanotubes. Journal of Nanoparticle Research 11:2, 477-484
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Ales Prokop, Jeffrey M. Davidson. (2008) Nanovehicular intracellular delivery systems. Journal of Pharmaceutical Sciences 97:9, 3518-3590
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D.W. Grainger, D.G. Castner. (2008) Nanobiomaterials and Nanoanalysis: Opportunities for Improving the Science to Benefit Biomedical Technologies. Advanced Materials 20:5, 867-877
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Cédric Klumpp, Lara Lacerda, Tatiana Da Ros, Kostas Kostarelos, Maurizio Prato, Alberto Bianco, Olivier Chaloin. (2007) Multifunctionalised cationic fullerene adducts for gene transfer: design, synthesis and DNA complexation. Chemical Communications :36, 3762
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Giorgia Pastorin, Wei Wu, Sébastien Wieckowski, Jean-Paul Briand, Kostas Kostarelos, Maurizio Prato, Alberto Bianco. (2006) Double functionalisation of carbon nanotubes for multimodal drug delivery. Chemical Communications :11, 1182
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Wei Wu, Sébastien Wieckowski, Giorgia Pastorin, Monica Benincasa, Cédric Klumpp, Jean-Paul Briand, Renato Gennaro, Maurizio Prato, Alberto Bianco. (2005) Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes. Angewandte Chemie 117:39, 6516
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Wei Wu, Sébastien Wieckowski, Giorgia Pastorin, Monica Benincasa, Cédric Klumpp, Jean-Paul Briand, Renato Gennaro, Maurizio Prato, Alberto Bianco. (2005) Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes. Angewandte Chemie International Edition 44:39, 6358
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Author:
Alberto Bianco
Keywords:
antigens
carbon nanotubes
drug delivery
gene transfer
peptides
plasmid DNA
vaccine delivery
vaccines