Expert Opinion on Drug Metabolism & Toxicology

About the Journal

Journal cover

EDITOR-IN-CHIEF: Luis Valerio Jr.

Commissioning Editor: Lizzie Howard

Production Manager: Jonathan Collard

2012 ISI Impact Factor 2.944

ISSN: 1742-5255 (print), 1744-7607 (electronic)

Latest News

  • Injurious therapeutics to fertility (includes free content!)

    April 22, 2022
    Journals across the Expert Collection have considered injurious therapeutics to fertility; offering a wealth of information for those prescribing and taking potentially toxic xenobiotics.
  • Pharmacokinetic investigation in children requires careful study planning and analysis

    April 9, 2022
    The editor’s pick form Dr Luis Valerio for the April issue of Expert Opinion on Drug Metabolism & Toxicology is a review paper by Dr Himebauch and Dr Zuppa of Philadelphia, entitled ‘Methods for pharmacokinetic analysis in young children’.
  • April Toxicology and Drug Metabolism News and Updates

    April 7, 2022
    Welcome to this month’s Toxicology and Drug Metabolism newsletter.

    Below you will find the latest published articles across all of Informa Healthcare’s Toxicology and Drug Metabolism journals. 

  • Editor-in-Chief picks review investigating the impact of inter-individual genetic difference on antiepileptic drugs

    February 26, 2022
    The editor’s pick from Dr Luis Valerio for the March issue of Expert Opinion on Drug Metabolism & Toxicology is a review article by Professor Oscar Della Pasqua and colleagues. Their review entitled ‘Implications of pharmacogenetics for the therapeutic use of antiepileptic drugs’ explores the inter-individual genetic differences that can lead to altered pharmacokinetics and pharmacodynamics of antiepileptic drugs.
  • Editor-in-Chief picks review exploring time-dependent CYP inhibition assays

    February 4, 2022
    The Editor’s pick from Dr Luis Valerio (Silver Spring, MD, USA) for the February issue of Expert Opinion on Drug Metabolism & Toxicology is ‘Exploring concepts of in vitro time-dependent CYP inhibition assays’. This article comes from David M Stresser et al. (Corning Life Sciences, USA) and you can read more here.
  • Editor’s Pick for January – Considering the effects of acute renal failure on drug metabolism

    January 8, 2022
    The Editor’s pick from Dr Luis Valerio (Silver Spring, MD, USA) for the January issue of Expert Opinion on Drug Metabolism & Toxicology is ‘The effects of acute renal failure on drug metabolism’. This article comes from Philips et al. (St. George’s, University of London, UK), click the link above to read more…
  • Expert Opinion considers alternatives to whole-animal testing

    December 20, 2013
    Want to learn more about some of the in vitro methods being used to discover and develop drugs? Both Expert Opinion on Drug Discovery and Expert Opinion on Drug Metabolism & Toxicology have been examining just that – click above to find out more.
  • Expert Opinion and Expert Reviews are now on facebook!

    December 18, 2013
    The Expert Opinion & Expert Reviews journals are now on facebook! Click here to visit our page and ‘LIKE’ us to keep updated of the newest articles and hottest news!
  • Editor’s Pick for December – reviewing the preclinical ADME data of FDA-approved small molecule kinase inhibitors

    December 4, 2013
    The Editor’s pick from Dr Luis Valerio (Silver Spring, MD, USA) for the December issue of Expert Opinion on Drug Metabolism & Toxicology is ‘Small molecule kinase inhibitors aproved by the FDA from 2000 to 2011: a systematic review of preclinical ADME data’. This article comes from O’Brien et al. (Celgene Corp., USA), click the link above to read more…
  • Editor’s Pick for November – how are biomarkers used to predict toxicity?

    November 6, 2013
    The Editor’s pick from Dr Luis Valerio (Silver Spring, MD, USA) for the November issue of Expert Opinion on Drug Metabolism and Toxicology is ‘The current status of biomarkers for predicting toxicity’. This article comes from Sarah Campion et al. (Pfizer, Inc., USA), click the link above to read more…
  • Toxicology & Drug Metabolism News: Editors’ picks, free article downloads and more

    November 5, 2013
    Welcome to the November issue of the Toxicology and Drug Metabolism newsletter.

    This month, we are pleased to offer you FREE access to 3 of the top downloaded articles from our Toxicology and Drug Metabolism journals

  • This Week in Expert Opinion

    October 22, 2013
    This Week in the Expert Opinion journals, we look into new and not-so-new therapies for cancer, the pharmacokinetics of a common contraceptive, and wonder what special considerations are needed for clinical trials of orphan drugs. Find out more here…
  • Editor’s Pick for October 2013

    October 4, 2013
    Our editor in chief has chosen the article entitled Streptomyces cytochromes P450: applications in drug metabolism” by David C Lamb, Michael R Waterman and Bin Zhao as the Editor’s pick for the October edition of the 2013 volume of Expert Opinion on Drug Metabolism and Toxicology.
  • Editor’s Pick for September 2013

    September 13, 2013
    Drug absorption, distribution, metabolism and excretion considerations in critically ill adults by Derek J Roberts and Richard I Hall
  • First-in-Class Drugs – pioneers with great potential!

    August 16, 2013
    The FDA defines a First-in-Class drug as one which uses a new and unique mechanism of action for treating a medical condition. This is a concept that immediately makes you think of words like ‘innovation’, ‘novelty’, ‘potential’, ‘pioneering’ and ‘cutting-edge’ – all things that most pharmaceutical companies look for when considering areas of R&D to pursue and invest in. While they have the potential to boost the company’s pipeline and its profit, First-in-Class drugs also come with much greater risk and are definitely not guaranteed to succeed.
  • Editor’s Pick for August 2013

    July 29, 2013
    Following the editorial highlight last week, we are happy to announce the Editor’s Pick for the recently published August issue of Expert Opinion on Drug Metabolism and Toxicology. This month’s selection is a review article on the “toxicty of topical ophthalmic anesthetics” written by M Patel and FW Fraunfelder.
  • Editorial Highlight: Depression in the elderly – what are the pharmacogenetic considerations? (August 2013)

    July 23, 2013
    The treatment of depression is, at the best of time, a complicated process that often relies on a number of different drugs being tested before the correct treatment is received. However, first-line therapy for depression has been shown to have a lower therapeutic outcome in the elderly.
  • Editorial Office News: New Original Research Article co-authored by our Editor in Chief, Luis Valerio Jr.

    July 18, 2013
    The editorial office is delighted to announce the publication of the Original Research Article “Development of cardiac safety translational tools for QT prolongation and torsade de pointes” in Expert Opinion on Drug Metabolism and Toxicology. Amongst the authors of this article is our Editor in Chief, Luis Valerio Jr.
  • Toxicology and Drug Metabolism Newsletter-July

    July 9, 2013
    Welcome to the July issue of the Toxicology and Drug Metabolism newsletter.

    This month, we are pleased to offer you FREE access to 3 of the top downloaded articles from our Toxicology and Drug Metabolism journals

  • Editor’s Pick for July 2013

    July 1, 2013
    Our editor in chief has chosen the article entitled “Microdosing and drug development: past, present and future” by Lappin G et al. as the Editor’s pick for the July edition of the 2013 volume of Expert Opinion on Drug Metabolism and Toxicology.
  • Toxicology and Drug Metabolism Newsletter-June

    June 14, 2013
    Welcome to the June issue of the Toxicology and Drug Metabolism newsletter.

    As part of our continued support and collaboration with you, we are pleased to offer you FREE access to these articles from our Toxicology and Drug Metabolism journals

     

  • Editor’s Pick for June 2013

    June 3, 2013
    Our editor in chief has chosen the article entitled “Optimizing the in vitro and clinical assessment of drug interaction risk by understanding co-medications in patient populations” by Bloomer et al as the Editor’s pick for the June edition of the 2013 volume of Expert Opinion on Drug Metabolism and Toxicology.
  • Toxicology and Drug Metabolism Newsletter_May

    May 13, 2013
    Toxicology and Drug Metabolism Newsletter_May
  • Editor’s Pick for May 2013

    April 29, 2013
    Our editor in chief has chosen the article entitled ” Cytochrome P450-mediated metabolism in brain: functional roles and their implications” by Ravindranath V and Strobel HW as the Editor’s pick for the May edition of the 2013 volume of Expert Opinion on Drug Metabolism and Toxicology.
  • Editor’s Pick for April 2013

    April 12, 2013
    Our editor in chief has chosen the article entitled “Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.” by H Barton, Y Lai, H Jones et al. as the Editor’s pick for the April edition of the 2013 volume of Expert Opinion on Drug Metabolism and Toxicology.
  • Editor’s Pick for March 2013

    April 11, 2013
    Our editor in chief has chosen the article entitled “Species differences in drug transporters and implications for translating preclinical findings to humans” by X Chu, K Bleasby and R Evers as the Editor’s pick for the March edition of the 2013 volume of Expert Opinion on Drug Metabolism and Toxicology.
  • Recent Publications on the Fixed Combination of Linagliptin + Metformin for the Treatment of Type II Diabetes

    March 14, 2013
    We have recently published two highly viewed drug evaluations on the fixed-combination drug of linagliptin and metformin (also known as Jentadueto®).
  • Editor’s Pick for EOMT January 2013

    January 11, 2013

    Our editor in chief has chosen the article entitled “GLP-1 agonists for type 2 diabetes: pharmacokinetic and toxicological considerations” by MJ Jespersen, FK Knop and M Christensen to be the first Editor’s pick for the January edition of the 2013 volume of Expert Opinion on Drug Metabolism and Toxicology.

  • Editors Pick for December 2012

    December 10, 2012

    This issue of the journal features an article on how in silico models for genotoxicity prediction have been evaluated including performance metrics.

    Latest advances in computational genotoxicity prediction by Russell Naven, Nigel Greene, Richard Williams is our Editor’s pick for December 2012.

  • Editor’s Pick November 2012

    October 26, 2012

    Pharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain (Niesters M and Dahan A)

    Our Editor’s pick for November Our Editor’s pick for November discusses the efficacy of subanesthetic doses of ketamine in alleviating chronic neuropathic pain, and highlights its pharmacokinetics and dynamics.

  • Editor’s Pick August 2012

    August 22, 2012

    Current regulatory approaches of bioequivalence testing (Karalis and Macheras)

    Our Editor’s pick for August reviews the current regulatory procedures on bioequivalence testing. Special focus is placed on the guidelines recommended by the European Medicines Agency and the US Food and Drug administration. The authors also describe the evolution of these issues and the alternatives proposed in the literature.

  • Editor’s Pick May 2012

    May 11, 2012

    Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants (Koturbash, Beland and Pogribny)

    Our Editor’s pick for May provides summarizes the current knowledge of the role of miRNAs in the regulation of drug (xenobiotic) metabolizing genes and the cellular responses to exposure to exogenous toxicants.

  • Editor’s Pick April 2012

    March 30, 2012

    In vitro-to-in vivo predictions of drug–drug interactions involving multiple reversible inhibitors (Lutz and Isoherranen)

    Our Editor’s pick for April provides an overview of the reliability of the in vitro determined reversible inhibition mechanism. Furthermore, the article provides a method to predict DDIs for multiple reversible inhibitors.

  • Let’s be clear – Expert Opinion on ethical publishing

    March 27, 2012
    In the interests of transparency, the editors would like to take the opportunity to update our readers on our ethical policies, and assure you that we take any breach of said policies very serieously, and will will investigate all such issues as fully as possible.
  • Toxicology and Drug Metabolism Newsletter – March 2012

    March 16, 2012

    Free access to the March edition of Informa Healthcare’s Toxicology and Drug Metabolism Newsletter

     

  • Editor’s Pick March 2012

    March 7, 2012

    Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions – (JD Clarke and NJ Cherrington)

    Our Editor’s pick for March discusses the role that Organic anion transporting polypeptides (OATP) play in adverse drug reactions, considered in the context of genetic or environmental factors.

  • Toxicology and Drug Metabolism Newsletter – February 2012

    February 21, 2012

    Free access to February edition of Informa Healthcare’s Toxicology and Drug Metabolism Newsletter.

  • Editor’s Pick February 2012

    February 16, 2012

    Standardization of pluripotent stem cell cultures for toxicity testing

    Pluripotent stem cell (PSC) lines offer a unique opportunity to derive various human cell types that can be exploited for human safety assessments in vitro and as such contribute to modern mechanistically oriented toxicity testing.

  • Informa Healthcare’s Toxicology and Drug Metabolism Newsletter – January 2012

    January 16, 2012
    FREE access to Informa Healthcare’s Toxicology and Drug Metabolism Newsletter – January 2012
  • Editor’s Pick January 2012

    January 10, 2012

    Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation

    Reliable in vitro and in silico assays as alternatives for in vivo developmental toxicity studies are urgently needed, for the replacement, reduction and refinement (3Rs) of animal use in toxicological research. Therefore, relevant biomarkers for in vivo developmental toxicity in in vitro assays are needed.

  • Toxicology and Drug Metabolism eNewsletter – December

    December 13, 2011

    FREE ACCESS to the December edition of Informa Healthcare’s Toxicology and Drug Metabolism eNewsletter: http://bit.ly/rTcG0U

     

  • Introducing Dr Luis Valerio Jr as the new Editor in Chief of Expert Opinion on Drug Metabolism and Toxicology

    November 2, 2011
    We are delighted to announce that Dr Luis Valerio Jr of the Center for Drug Evaluation and Research, FDA, has accepted our invitation to become the first Editor in Chief of Expert Opinion on Drug Metabolism and Toxicology.